Table 5. Concentrations and activities of selected haemostatic parameters depending on clinicopathological parameters in BrCa patients free of coexisting diseases (n=53).
| Coagulation assays | TF activity | TF concentration | TF/TFPI activity ratio | TFPI activity | TFPI concentration | TF/TFPI concentration ratio | t-PA concentration | PAI-1 concentration |
|---|---|---|---|---|---|---|---|---|
| P=values | P=values | P=values | P=values | P=values | P=values | P=values | P=values | |
| Age <55 years | 14.99/11.59/24.17 | 564.16/383.00/649.85 | 11.02/8.28/25.41 | 1.28/0.94/1.42 | 39.00/31.92/46.44 | 14.02/8.43/20.36 | 4.55/3.92/5.98 | 37.20/26.42/56.19 |
| Age ≥55 years | 25.72/13.24/35.28 | 542.92/441.94/698.45 | 21.46/10.02/29.95 | 1.26/1.13/1.44 | 47.58/40.92/66.62 | 10.68/9.57/12.23 | 6.09/3.72/7.06 | 38.47/24.29/46.37 |
| P=0.0712 | P=0.5757 | P=0.2217 | P=0.8640 | P=0.0160 | P=0.2987 | P=0.3204 | P=0.6560 | |
| Localization of tumour: left breast | 23.14/11.38/37.64 | 566.31/458.45/670.18 | 17.11/7.88/31.58 | 1.34/0.99/1.41 | 44.74/36.96/62.28 | 11.50/8.19/20.22 | 4.93/4.05/6.65 | 44.19/32.28/57.98 |
| Localization of tumour: right breast | 13.96/12.46/26.92 | 500.39/392.64/710.40 | 11.54/10.09/22.43 | 1.20/1.10/1.50 | 40.68/32.96/50.80 | 11.75/9.77/18.46 | 5.26/3.92/6.34 | 35.12/22.22/39.39 |
| P=0.5315 | P=0.3006 | P=0.5466 | P=0.6008 | P=0.4460 | P=0.9004 | P=0.8112 | P=0.0250 | |
| Ki67 ≤14 % | 19.79/12.46/28.76 | 530.35/383.00/649.85 | 15.11/9.95/29.99 | 1.23/0.84/1.34 | 44.74/39.00/64.24 | 10.49/9.36/14.02 | 4.35/3.24/6.25 | 38.54/24.18/48.12 |
| Ki67 ≥15% | 18.21/11.59/31.56 | 563.96/444.32/686.50 | 16.21/8.65/25.81 | 1.36/1.14/1.42 | 40.12/31.96/59.60 | 12.67/8.65/21.60 | 5.87/4.42/6.86 | 36.53/26.42/53.01 |
| P=0.7329 | P=0.4193 | P=0.5618 | P=0.2953 | P=0.1138 | P=0.0901 | P=0.0370 | P=0.9909 | |
| Clinical classification TNM - pT1 (a, b, c) | 21.16/12.31/29.59 | 547.45/402.49/653.85 | 16.54/8.73/29.99 | 1.28/0.84/1.42 | 43.84/36.28/64.24 | 11.07/8.65/17.05 | 4.44/3.24/6.34 | 41.15/26.42/57.65 |
| Clinical classification- TNM - pT2 | 13.88/12.31/26.92 | 563.96/431.59/728.94 | 14.57/10.09/20.49 | 1.26/1.20/1.38 | 42.36/35.60/46.44 | 12.67/9.77/20.36 | 5.87/4.83/6.44 | 36.50/24.40/38.56 |
| P=0.5395 | P=0.6253 | P=0.6077 | P=0.9601 | P=0.4754 | P=0.4015 | P=0.0375 | p = 0.1723 | |
| Histological type- IDC | 18.92/12.39/29.18 | 559.47/401.68/651.85 | 16.54/9.19/29.95 | 1.28/1.02/1.41 | 41.54/35.32/60.74 | 11.25/8.54/18.28 | 5.20/3.93/6.65 | 38.54/25.45/54.60 |
| Histological type- ILC | 12.82/11.80/26.92 | 613.22/520.76/728.94 | 10.17/8.73/18.68 | 1.30/1.20/1.60 | 44.32/35.60/44.80 | 15.04/11.38/20.18 | 5.05/4.14/6.16 | 30.24/24.18/35.12 |
| P=0.4518 | P=0.2969 | P=0.2969 | P=0.3832 | P=0.8241 | P=0.3832 | P=0.9864 | p = 0.1660 | |
| Luminal A type of BrCa (n=38) | 14.10/12.31/26.92 | 539.93/431.59/653.85 | 12.16/9.73/25.81 | 1.26/1.10/1.40 | 44.80/37.12/60.16 | 10.75/8.77/17.05 | 4.55/3.45/6.22 | 38.56/28.10/45.48 |
| Other molecular types of BrCa (n=15) | 23.14/14.18/39.16 | 547.41/439.56/718.70 | 18.80/8.98/30.99 | 1.38/1.14/1.42 | 38.36/32.96/43.44 | 13.71/8.89/20.92 | 5.79/4.42/6.86 | 38.35/27.73/53.01 |
| P=0.1636 | P=0.9243 | P=0.3926 | P=0.3422 | P=0.0396 | P=0.1424 | P=0.3161 | p = 0.6806 |
Data are expressed as median (Me) and the IQR (lower quartile (Q1, upper quartile (Q3)); TNM classification of malignant tumours. Abbreviations: IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma.
Significant differences are denoted by bold P-values.