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. 2018 Mar 22;9:592. doi: 10.3389/fimmu.2018.00592

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Copyright © 2018 Liu, King, Bouillet, Tarlinton, Strasser and Heierhorst.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro activation of purified B cells. (A) Representative FACS plots and CTV-dilution profiles of B cells purified from Cd23-Cre control and Cd23-Cre Bim^fl/f^l mice after 4 days of treatment with 15 µg/mL lipopolysaccharide (LPS). (B) Gating strategies to distinguish small non-responding B lymphocytes from large activated B lymphoblasts, and separated CTV dilution profiles for each fraction. (C) Quantification of the cell division index for the entire LPS-treated cultures. (D) Quantification of the cell proliferation index (division index excluding cells with undiluted CTV) of LPS-treated cultures. (E,F) Cell division and proliferation indices of similar CD40L + IL4-treated B cell cultures.