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Wild-type JC pseudovirus but not L54F or S268F mutants transduce SVG-A, CPEpiC, and HMC. Luciferase-expressing pseudoviruses were prepared using wild-type VP1 (JCPsV-WT) or with two sialic acid pocket mutants of VP1 (L54F and S268F). The wild-type pseudovirus readily transduced all three cell types, but neither of the mutants transduced any of the cells above the mock control. Error bars represent standard errors of the mean for three independent experiments performed in triplicate.
