FIG 1.

Binding plasma IgG titers primed by NYVAC vector immunization are boosted by protein immunization. (A) Immunization and challenge schedule for Indian origin rhesus macaques. Macaques were immunized with 10⁸ PFU of NYVAC encoding gp120 and subsequently boosted with recombinant gp120 protein. Macaques were challenged weekly with an intrarectal administration of a 1:400 dilution of tier 2 CCR5-tropic SHIV SF162P3. (B) Binding plasma IgG against each vaccine immunogen was analyzed over time in the vaccinated macaques. The binding antibody titers are depicted as log area under the curve (AUC). The values are the means and SDs for all six animals. Each graph shows the plasma IgG binding titer for all three groups (blue, red, and green lines) to the antigen listed.