FIG 7.

Lack of protection from tier 2 SHIV SF162P3 low-dose, repetitive intrarectal challenge. (A) Log rank tests for the Kaplan-Meier curve for infection during the repetitive low-dose intrarectal challenge of macaques vaccinated with all three Envs. The first challenge occurred 2 weeks after the fifth protein boost. Naive animals were included as positive controls for challenge. Vaccine efficacy statistics are presented in Table 2. (B) Plasma viral load of the challenged animals over time. The limit of detection is 100 copies/ml. Each line represents an individual macaque. Each group immunogen is listed above the panel, and the lines are color-coded as indicated in panel A. (C) Comparison of peak vial load across vaccinated and control groups. Each column represents one group, and individual macaques are shown by each symbol. TCM, T cell mosaic.