FIG 5 .
Mice immunized with 1 µg InvaplexAR experience less weight loss and recover more rapidly than those immunized with InvaplexNAT. Mice immunized with S. flexneri 2a InvaplexAR (red) or InvaplexNAT (blue) were challenged intranasally with a lethal dose of S. flexneri 2a strain 2457T. Mice were weighed on the day of challenge and each day for 14 days postchallenge. The average weight for each group was calculated, and the difference was expressed as a percentage of the change in weight from the prechallenge values. The numbers of surviving animals/animals in groups immunized with InvaplexNAT and InvaplexAR are shown. While protection was significant for both products compared to saline controls, a significant difference in weight was observed for the 1-µg InvaplexAR group compared to the 1-µg InvaplexNAT group (*, P = 0.0126).