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. 2018 Jan 10;6(1):5. doi: 10.3390/vaccines6010005

Figure 4.

Figure 4

Biosafe strain-derived OMVs produce B. mallei and B. pseudomallei specific serum antibody responses. (A) Serum antibody responses in vehicle only or OMV-vaccinated mice (PBS n = 5, all others n = 10) to B. mallei China 7 lysate. (B) Serum antibody responses in vehicle only or OMV-vaccinated mice to B. pseudomallei 1026b lysate (PBS n = 5, all others n = 10). Measured by ELISA and represented as absorbance units at 450 nm. (C,D) Serum IgG1 and IgG2a responses in vehicle only or OMV-vaccinated mice (PBS n = 5, all others n = 10) to B. mallei China 7 lysate expressed at reciprocal endpoint titer. One-way ANOVA was used to determine statistical significance, ns p > 0.05, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.