Table 1.
Efficacy of postexposure combination therapy.
| Treatment | Host (Pathogen) | Incubation Period | Therapeutic Value | Ref. |
|---|---|---|---|---|
| Vaccine | Human | 7–14 | Effective up to 4 days postexposure (anecdotal). | [85,139,140] |
| Vaccine (Lister, MVA) | Mouse (ECTV) | 6 | Effective up to 4 days postexposure (Lister 108, MVA 108). | [53] |
| Vaccine + VIG | Mouse (ECTV) | 6 | Maintains vaccine efficacy. Effective up to 3 days postexposure. | [120] |
| Vaccine (Lister, MVA) + CDV | Mouse (ECTV) | 6 | Maintains vaccine efficacy. Effective up to 3 days postexposure. | [115] |
| Vaccine + CMX001 | Mouse (ECTV) | 6 | Effective 2 days postexposure (no data on delayed treatment). Maintains vaccine efficacy. | [145] |
| Vaccine + ST-246 | Mouse (VACV-WR) | 3 | Maintains vaccine efficacy. Effective up to 3 days postexposure. | [134,144] |
| NHP (MPXV) | 2–3 | Effective 3 days postexposure (no data on delayed treatment). Maintains vaccine efficacy. | [133] | |
| Vaccine (Lister) + Poly(I:C) | Mouse (ECTV) | 6 | Effective up to 5 days postexposure. | [13] |