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TcDNA-ASOs mechanisms of action. TcDNA, as other ASOs, may exert different effects depending on their structure and design. Fully modified tcDNA (right panel) are not able to elicit RNAse H activity and they are commonly used to manipulate alternative splicing (exon skipping, exon inclusion and correction of aberrant splice sites) or to prevent protein binding (steric blocking). However, in order to induce mRNA degradation via RNAse H, tcDNA must be designed as gapmers (left panel).
