Table 2.
Gene (Gene ID *; Origin, If Different) | Object | Overexpression Specificity | Agents | R * | References |
---|---|---|---|---|---|
Genes involved in DNA damage recognition and repair | |||||
mus210 (36697) | D. melanogaster | ubiquitous | γ-ray | 0 | [190] |
paraquat | ↓ | [191] | |||
mei9 (31373) | D. melanogaster | ubiquitous | γ-ray | ↓ | [190] |
paraquat | ♂—↑; ♀—0 | [191] | |||
neurospecific | paraquat | ↓ | [191] | ||
Rrp1 (33500) | D. melanogaster | ubiquitous | paraquat | ♂—↑; ♀—0 | [191] |
γ-ray | ↓ | [190] | |||
Ku80 (34930) | D. melanogaster | ubiquitous | γ-ray | 0 | [190] |
paraquat | ♂—↑; ♀—0 | [191] | |||
Brca2 (37916) | D. melanogaster | ubiquitous | γ-ray | 0 | [190] |
spnB (41746) | D. melanogaster | ubiquitous | γ-ray | 0 | [190] |
dPrp19 (37123) | D. melanogaster | ubiquitous | paraquat, cisplatin | ♀—↑ | [192] |
Ada (946710; E. coli) and its truncated and modified versions | M. musculus | ubiquitous | dimethylnitrosamine, diethylnitrosamine | ↑ | [193] |
hepatic | MNU, nitrosodimethylamine | ↑ | [194] | ||
MGMT (4255) and its modified versions | M. musculus | bone marrow | alkylating agents | ↑ | [119,120,124,195] |
ubiquitous but predominantly in the thymus | alkylating agents | ↑ | [53,55,56,196,197,198] | ||
epidermal | alkylating agents | ↑ | [51,199] | ||
lung | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone | ↑ | [54] | ||
Genes involved in detoxification and efflux of free radicals and xenobiotics | |||||
Gclc (53581) | D. melanogaster | ubiquitous | paraquat | ↑ | [200] |
SOD1 (6647) | D. melanogaster | motorneurons | paraquat | ↑ | [201] |
γ-ray | ↑ | [201] | |||
ubiquitous | paraquat | 0 | [202] | ||
M. musculus | ubiquitous | benzo(a)pyrene | ↑ | [203,204] | |
SOD2 (36878) | D. melanogaster | ubiquitous | 100% O2 | 0 | [205] |
EC-SOD (6649) | M. musculus | alveolar type II and nonciliated distal bronchial epithelial cells | 4-MV photons | ↑ | [206] |
CAT (847) | D. melanogaster | ubiquitous | H2O2 | ↑ | [207] |
M. musculus | heart-specific | doxorubicin | ↑ | [208] | |
ubiquitous | benzo(a)pyrene | ↑ | [203,204] | ||
proton irradiation | ↑ | [209,210] | |||
MTII (17750) | M. musculus | ubiquitous | streptozotocin | ↑ | [129] |
Genes involved in control of proliferation and cell cycle | |||||
Mnk (35288) | D. melanogaster | neurospecific | paraquat | ↓ | [191] |
dGADD45 (35646) | D. melanogaster | ubiquitous | γ-ray | ↓ | [190] |
neurospecific | paraquat | ♂—↑; ♀—0 | [211] | ||
γ-ray | 0 | [211] | |||
Genes involved in regulation of apoptosis | |||||
BCL2 (596; human) | M. musculus | ubiquitous | X-ray | ↑ | [212] |
Genes with other function | |||||
WRNexo (42208) | D. melanogaster | neurospecific | paraquat | ↓ | [191] |
ubiquitous | γ-ray | 0 | [190] | ||
Per (31251) | D. melanogaster | neurospecific | paraquat | ↑ | [213] |
CLOCK (38872) | D. melanogaster | neurospecific | paraquat | ↑ | [213] |
Cyc (40162) | D. melanogaster | neurospecific | paraquat | ↓ | [213] |
IGF1R_(3480; human) | KSN nude M. musculus | tumor generated by transgenic HeLa cells | X-ray | ↑ | [153] |
Sirt1 (93759) | M. musculus | heart-specific | paraquat | ↑ | [214] |
VASH1 (22846; human) | M. musculus | intratracheally infected with adenovirus vector encoding human VASH1 | paraquat | ↑ | [164] |
dFOXO (41709) | D. melanogaster | pericerebral fat body | paraquat | ↑ | [215] |
Gene ID *—EntrezGene ID for the organism from which the cDNA originated. When listed experiments performed in different species the human EntrezGene ID are specified. R *—resistance estimated based on survival, growth inhibition, DNA damage, mutagenesis or neoplastic transformation andpoints.