Table 1.

Main RNA-therapy studies in amyotrophic lateral sclerosis.

Year	Reference	Organism			Gene Target				Therapeutic Strategy
		Animal	Human Cells	Human	SOD1	C9ORF72	FUS	ATXN2	ASOs	SMT	GT
2003	Ding et al. [8]	D			+					+
2005	Miller et al. [9]	M			+					+
2005	Ralph et al. [10]	M			+					+
2006	Smith et al. [11]	R/NHP			+				+
2013	Donnelly et al. [12]		+			+			+
2013	Foust et al. [13]	M			+					+
2013	Koval et al. [14]	M			+					+
2013	Lagier-Tourenne et al. [15]	M	+			+			+
2013	Miller et al. [16]			+	+				+
2013	Sareen et al. [17]		+			+			+
2015	Butovsky et al. [18]	M			+					+
2016	Borel et al. [19]	M/NHP			+					+
2016	Jiang et al. [20]	M				+			+
2017	Becker et al. [21]	M						+	+
2017	Biferi et al. [22]	M			+					+
2017	Wang et al. [23]		+		+		+
2017	Chen et al. [24]	Z			+				+

ASOs: antisense oligonucleotides; D: drosophila; GT: gene therapy; M: mouse; NHP: nonhuman primate; R: rat; SMT: small molecule therapy; Z: zebrafish.