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Comparison of mean tumor volumes (±SEM) in mice with human NSCLC. NCI-H460 implants treated with NUC050, NUC052 or gemcitabine (n =10 per group). SC mice are those treated contemporaneously with NUC050, NUC052 or gemcitabine 120/80 mg/kg as per regimen in Figure 3. Historic SC mice were from a previous experiment comparing SC to gemcitabine 135 mg/kg IV q5d × 3.
