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Comparison of GI50 of gemcitabine, NUC050 and NUC024 in the presence or absence of dipyridamole (DP).
| GI50 (μM) | ||||||
|---|---|---|---|---|---|---|
| Breast MDA-MB-231 | Non-Small Cell Lung NCI-H460 | Colon HCT116 | ||||
| Compound | DP (−) | DP (20 μM) | DP (−) | DP (20 μM) | DP (−) | DP (20 μM) |
| Gemcitabine | 3.08 | 56.77 | 0.02 | 0.82 | 0.03 | 2.39 |
| NUC050 | 17.16 | 23.30 | 2.14 | 1.47 | 3.07 | 6.74 |
| NUC024 | 30.34 | 27.77 | 7.16 | 15.98 | 5.55 | 12.61 |
