Table 4.
Pharmacokinetic parameters after 2 mg/kg IV NUC050 administration in mice. Where, T1/2: half-life, C0: concentration at time 0, AUClast: area under the curve to the last time point, AUCinf: area under the curve extrapolated to infinity, AUC Ext: Proportion of AUC extrapolated, Vss: volume of distribution at a steady state, CL: clearance, MRT: mean residence time.
| T1/2 (h) | C0 (ng/mL) | AUClast (h·ng/mL) | AUCinf (h·ng/mL) | AUC Ext (%) | Vss (L/kg) | CL (mL/min/kg) | MRT (h) |
|---|---|---|---|---|---|---|---|
| 3.9 | 42,351 | 19,028 | 19,101 | 0.38 | 0.2 | 0.8 | 1.8 |