Table 2.
Effects of different LMWC concentrations in the aqueous phase during the creation of PLGA NPs loaded with tobramycin based on size (nm), polydispersity index (PDI), charge (mV), drug entrapment efficiency (EE) (percentage), and loading capacity (LC) (percentage).
| Formulae | Size (nm) | PDI | Zeta Potential (mV) | EE (%) | LC (%) |
|---|---|---|---|---|---|
| Control | 187.00 ± 6.19 | 0.206 ±0.014 | +45.00 ± 4.30 | NA | NA |
| F0 | 220.70 ± 1.77 | 0.194 ±0.002 | −2.80 ± 0.10 | 85.34% | 45.92% |
| F0.25 | 309.57 ± 1.12 | 0.295 ±0.011 | +34.00 ± 1.90 | 88.47% | 43.15% |
| F0.5 | 451.80 ± 7.19 | 0.297 ±0.106 | +50.13 ± 6.50 | 87.20% | 37.33% |
| F1 | 575.77 ± 2.67 | 0.319 ±0.130 | +33.47 ± 1.00 | 83.74% | 30.87% |