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. 2018 Feb 6;7(1):19. doi: 10.3390/pathogens7010019

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Caseating Granulomas in Humans and Mice (35). C57Bl/6 mice produce classic pulmonary caseating granulomas following injection of a high dose of MTB in oil into the lungs of a sensitized animals (LEFT). Human caseating granuloma for comparison (MIDDLE). Mice injected i.v. with MTB one day after i.p injection of TDM in oil produce caseating granulomas with a fibrous capsule in the peritoneal cavity. (RIGHT, Trichrome connective tissue stain). This lesion contained many MTB after most had been eliminated from other parts of the body. Rupture of the capsule of this type of lesion was associated with reactivation TB in the lungs (Photos at 20× Mag).