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MTB antigen in a Macaque lung at 4 months after infection. MTB antigen (brown IHC stain) is present alveolar macrophages just outside of a granuloma. Earlier time points showed MTB antigen only in granulomas. This pattern of MTB antigen in alveolar macrophages outside of granulomas is typical of the earliest stage of post-primary TB in humans and mice. (IHC stain for MTB at 400× left and 40× right).
