Table 2.
List of the Top 10 pathways, which were affected by the up- or down-regulated proteins for the DM patient. In total, 340 and 344 proteins were analyzed, respectively.
| Pathway (Increased) | Count | p Value |
|---|---|---|
| Diseases of signal transduction | 50 | 1.11 × 10−16 |
| Signaling by Receptor Tyrosine Kinase | 53 | 1.11 × 10−16 |
| PI3K/AKT Signaling in Cancer | 25 | 1.11 × 10−16 |
| Signal Transduction | 102 | 4.44 × 10−16 |
| Intracellular signaling by second messengers | 32 | 1.22 × 10−15 |
| Disease | 62 | 1.78 × 10−15 |
| PIP3 activates AKT signaling | 30 | 3.33 × 10−15 |
| Negative regulation of the PI3K/AKT network | 21 | 6.11 × 10−15 |
| Signaling by FGFR in disease | 17 | 4.52 × 10−14 |
| Signaling by SCF-KIT | 14 | 1.62 × 10−13 |
| Pathway (Decreased) | Count | p Value |
| Neutrophil degranulation | 64 | 1.11 × 10−16 |
| Platelet degranulation | 30 | 1.11 × 10−16 |
| Regulation of IGF transport and uptake by IGFBPs | 31 | 1.11 × 10−16 |
| Innate immune system | 100 | 1.11 × 10−16 |
| Response to elevated platelet cytosolic Ca2+ | 30 | 2.22 × 10−16 |
| Post-translational protein phosphorylation | 27 | 4.44 × 10−16 |
| Homeostasis | 63 | 1.67 × 10−12 |
| Platelet activation, signaling and aggregation | 36 | 2.70 × 10−13 |
| Immune system | 121 | 4.97 × 10−10 |
| Binding and Uptake of Ligands by Scavenger Receptor | 21 | 2.21 × 10−9 |