Table 3.
The association of the levels of 30 cytokines with grade ≥2 RE in 129 NSCLC patients in univariate analysis (cytokine levels are log-transformed).
| Cytokine | Absolute pre
|
Absolute 2w
|
Absolute 4w
|
Ratio 2w/pre
|
Ratio 4w/pre
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | p | OR(95%CI) | p | OR(95%CI) | p | OR(95%CI) | p | OR(95%CI) | p | |
| EGF | 1.01(0.82, 1.23) | 0.917 | 1.05(0.85, 1.29) | 0.669 | 0.93(0.74, 1.17) | 0.542 | 0.99(0.99, 1.00) | 0.552 | 0.99(0.98, 1.01) | 0.841 |
| Eotaxin | 0.59(0.36, 0.99) | 0.045 | 0.51(0.30, 0.86) | 0.012 | 0.59(0.34, 1.04) | 0.068 | 0.99(0.98, 0.99) | 0.021 | 0.99(0.99, 1.00) | 0.577 |
| Fractalkine | 1.02(0.86, 1.20) | 0.820 | 1.04(0.88, 1.23) | 0.627 | 1.04(0.88, 1.25) | 0.636 | 0.99(0.99, 1.00) | 0.193 | 0.99(0.99, 1.00) | 0.119 |
| GCSF | 0.88(0.73, 1.05) | 0.164 | 0.82(0.66, 1.02) | 0.081 | 0.94(0.75, 1.17) | 0.568 | 1.00(0.99, 1.00) | 0.766 | 1.00(0.99, 1.00) | 0.370 |
| GMCSF | 0.97(0.81, 1.16) | 0.737 | 0.95(0.80, 1.14) | 0.582 | 0.96(0.79, 1.16) | 0.652 | 0.99(0.99, 1.00) | 0.568 | 0.99(0.99, 1.00) | 0.500 |
| IFN | 0.94(0.74, 1.18) | 0.578 | 1.00(0.80, 1.25) | 1.000 | 0.93(0.73, 1.18) | 0.566 | 1.00(0.99, 1.00) | 0.580 | 1.00(0.99, 1.00) | 0.634 |
| IL-10 | 1.08(0.92, 1.27) | 0.362 | 1.04(0.90, 1.21) | 0.587 | 1.12(0.94, 1.33) | 0.205 | 1.00(0.99, 1.01) | 0.859 | 1.00(0.99, 1.01) | 0.278 |
| IL-12p40 | 1.05(0.90, 1.23) | 0.503 | 0.99(0.86, 1.15) | 0.929 | 0.98(0.84, 1.15) | 0.837 | 0.99(0.99, 1.00) | 0.386 | 0.99(0.99, 1.00) | 0.473 |
| IL-12p70 | 1.03(0.86, 1.25) | 0.742 | 0.94(0.77, 1.15) | 0.551 | 0.98(0.80, 1.19) | 0.807 | 0.99(0.98, 1.01) | 0.453 | 1.00(0.99, 1.01) | 0.479 |
| IL-13 | 1.26(1.04, 1.53) | 0.021 | 1.24(1.03, 1.51) | 0.026 | 1.17(0.96, 1.42) | 0.116 | 0.99(0.99, 1.01) | 0.892 | 0.99(0.98, 1.00) | 0.253 |
| IL-15 | 1.19(0.95, 1.5) | 0.124 | 1.32(1.02, 1.71) | 0.035 | 1.30(0.95, 1.78) | 0.104 | 0.99(0.98, 1.01) | 0.730 | 1.00(0.98, 1.02) | 0.565 |
| IL-17 | 1.06(0.88,1.28) | 0.517 | 1.04(0.87, 1.25) | 0.681 | 1.03(0.85, 1.25) | 0.763 | 0.99(0.98, 1.01) | 0.627 | 0.99(0.98, 1.01) | 0.588 |
| IL-1 | 0.95(0.79, 1.14) | 0.564 | 0.97(0.81, 1.15) | 0.702 | 0.89(0.75, 1.06) | 0.192 | 0.99(0.99, 1.00) | 0.595 | 1.00(0.99, 1.00) | 0.942 |
| IL-1 | 1.14(0.96, 1.34) | 0.127 | 1.10(0.93, 1.29) | 0.260 | 1.10(0.94, 1.29) | 0.248 | 0.99(0.98, 1.01) | 0.554 | 0.99(0.97, 1.02) | 0.764 |
| IL-1r | 1.15(0.98, 1.36) | 0.081 | 1.07(0.92, 1.26) | 0.376 | 0.98(0.83, 1.15) | 0.776 | 0.99(0.99, 1.00) | 0.221 | 0.99(0.99, 1.00) | 0.204 |
| IL-2 | 1.15(0.95, 1.39 | 0.165 | 1.09(0.91, 1.32) | 0.357 | 1.05(0.87, 1.27) | 0.603 | 0.99(0.98, 1.00) | 0.405 | 1.00(0.99, 1.01) | 0.791 |
| IL-4 | 0.95(0.82, 1.11) | 0.535 | 0.97(0.83, 1.14) | 0.721 | 0.86(0.73, 1.02) | 0.088 | 1.00(0.99, 1.01) | 0.683 | 0.99(0.99, 1.00) | 0.623 |
| IL-5 | 1.06(0.89, 1.27) | 0.497 | 1.02(0.86, 1.22) | 0.782 | 0.95(0.81, 1.12) | 0.535 | 0.86(0.72, 1.01) | 0.065 | 0.93(0.85, 1.01) | 0.083 |
| IL-6 | 1.02(0.85, 1.22) | 0.867 | 0.95(0.80, 1.15) | 0.614 | 0.93(0.77, 1.12) | 0.419 | 0.99(0.98, 1.01) | 0.724 | 0.99(0.99, 1.01) | 0.808 |
| IL-7 | 1.13(0.89, 1.43) | 0.315 | 0.96(0.76, 1.23) | 0.768 | 1.04(0.81, 1.34) | 0.743 | 0.99(0.96, 1.02) | 0.547 | 0.99(0.97, 1.02) | 0.769 |
| IL-8 | 0.65(0.45, 0.94) | 0.021 | 0.73(0.52, 1.01) | 0.054 | 0.74(0.52, 1.07) | 0.115 | 0.99(0.98-1.02) | 0.717 | 1.01(0.98, 1.04) | 0.331 |
| IP10 | 0.96(0.77, 1.19) | 0.698 | 0.93(0.75, 1.15) | 0.505 | 0.93(0.75, 1.14) | 0.464 | 1.00(0.99-1.00) | 0.690 | 1.00(0.99-1.10) | 0.743 |
| MCP1 | 1.08(0.75, 1.56) | 0.677 | 1.09(0.81, 1.46) | 0.565 | 0.96(0.68, 1.34) | 0.797 | 0.99(0.99-1.00) | 0.344 | 0.99(0.99, 1.00) | 0.527 |
| MIP1 | 1.03(0.81, 1.3) | 0.820 | 1.00(0.81, 1.23) | 0.964 | 0.96(0.75, 1.24) | 0.767 | 0.99(0.98-1.00) | 0.256 | 0.99(0.99, 1.01) | 0.791 |
| MIP1 | 1.01(0.79, 1.29) | 0.923 | 0.99(0.76, 1.28) | 0.942 | 0.96(0.73, 1.26) | 0.791 | 0.99(0.99-1.00) | 0.658 | 0.99(0.99, 1.00) | 0.419 |
| sCD40L | 1.05(0.93, 1.19) | 0.403 | 1.05(0.93, 1.19) | 0.407 | 1.02(0.90, 1.15) | 0.734 | 1.00(0.99-1.00) | 0.461 | 1.00(0.99, 1.00) | 0.287 |
| TGF | 1.21(1.00, 1.47) | 0.054 | 1.16(0.97, 1.39) | 0.102 | 1.12(0.93, 1.36) | 0.233 | 1.00(0.97-1.03) | 0.891 | 0.99(0.97, 1.01) | 0.434 |
| TNF | 0.94(0.67, 1.31) | 0.713 | 1.01(0.77 1.33) | 0.945 | 0.94(0.67, 1.31) | 0.716 | 1.00(0.98-1.02) | 0.924 | 0.99(0.98, 1.02) | 0.703 |
| VEGF | 0.90(0.73, 1.11) | 0.318 | 0.99(0.79, 1.23) | 0.894 | 0.95(0.77, 1.17) | 0.621 | 0.99(0.99-1.00) | 0.590 | 0.99(0.99, 1.00) | 0.241 |
| TGF1 | 1.20(0.84, 1.71) | 0.319 | 1.11(0.81, 1.53) | 0.522 | 0.93(0.65, 1.32) | 0.684 | 0.95(0.89-1.02) | 0.163 | 0.94(0.87, 1.00) | 0.068 |