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Polyethylenglycol (PEG) conjugation to the polylactide-co-glycolide (PLGA) polymer: (A) PEG conjugation throughout the PLGA polymerization reaction; (B) PEG conjugation to premade PLGA; (C) PEG conjugation to previously formed nanoparticles. (Modified from Bentacourt and co-workers. 2009 [57]).
