Table 1.
System-related parameters used for the rat whole-body PBPK model.
| Tissue | Perfusion | Volume | ||
|---|---|---|---|---|
| Rat | Human | Rat | Human | |
| (mL/min) | (mL/min) | (mL) | (mL) | |
| Adipose | 4.72 | 277.5 | 19.03 | 10,725 |
| Bone | 8.08 | 270 | 10.37 | 9300 |
| Brain | 1.12 | 750 | 1.43 | 1552.5 |
| Gut | 12 | 975 | 6.75 | 1770 |
| Heart | 3.2 | 160.5 | 0.825 | 285 |
| Kidney | 11.6 | 1177.5 | 1.825 | 330 |
| Liver | 20 | 1575 | 10.3 | 1807.5 |
| Lungs | 80 | 5325 | 1.25 | 1252.5 |
| Muscle | 18.96 | 802.5 | 101 | 32,175 |
| Pancreas | 1 | 142.5 | 1.3 | 90 |
| Skin | 4.08 | 322.5 | 47.5 | 8325 |
| Spleen | 0.88 | 82.5 | 0.5 | 202.5 |
| Arterial blood | - | - | 6.8 | 1927.5 |
| Venous blood | - | - | 13.6 | 3855 |