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Results obtained after p.o. administration of (S)-ketoprofen alone (3.2 mg/kg) and in combination with caffeine (17.8 mg/kg) to male Wistar rats (Mean ± SEM, n = 6/group). (A) Plasma concentration–time curves. (B) Antinociceptive effect–time curves. (C) Antinociceptive effect vs. plasma concentrations. (D) Cumulative AUCe as a function of cumulative AUCp, data adjusted to sigmoidal Emax model.
