Table 1.
The type and amounts of ingredients used in the taste-masked rapidly-disintegrating sublingual tablet formulations 1.
| Ingredient (mg) 2 | Formulations | |
|---|---|---|
| Placebo | Epi 30 | |
| Epinephrine bitartrate | 0 | 54.58 |
| Microcrystalline cellulose (Ceolus® PH-301) | 123.00 | 80.86 |
| Microcrystalline cellulose (Ceolus® PH-M-06) | 20.50 | 13.48 |
| Mannitol (Ludiflash) | 34.10 | 34.10 |
| Citric acid | 2.50 | 2.50 |
| Low-substituted hydroxypropyl cellulose (LH11) | 15.90 | 10.48 |
| Magnesium stearate | 4.00 | 4.00 |
1 Tablet weight was maintained at 200 mg; 2 Ratio of total microcrystalline cellulose (Ceolus® PH-301 and Ceolus® PH-M-06) to low-substituted hydroxypropyl cellulose (LH11) was kept at 9:1 in both formulations.