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. 2018 Mar 11;10(1):32. doi: 10.3390/pharmaceutics10010032

Figure 8.

Figure 8

Cellular uptake of free DOX, DOX-CA NPs and DOX-CMCA NPs. (A) fluorescence intensity measuring DOX (1 µM) uptake with MCF-7 cells at 1 h of treatment; (B) fluorescence intensity measuring DOX (5 µM) uptake with MCF-7 cells at 1 h of treatment; (C) fluorescence intensity measuring DOX (1 µM) uptake with MCF-7 cells at 4 h of treatment; (D) fluorescence intensity measuring DOX (5 µM) uptake with MCF-7 cells at 4 h of treatment. Values were significant (*) at p-value < 0.05, extremely significant (**) at p-value < 0.0001 vs. untreated cells at CI of 95%.