FIG 4.

Key amino acid residues necessary for PltB binding to sugar moieties are also present in ArtB. (A) Alignments of translated amino acid sequences of PltB and ArtB from S. Javiana strain CFSAN0001992 and PltB from S. Typhi strain CT-18. Key residues that are conserved are shown on light blue background. Residues that differ between S. Typhi PltB and S. Javiana ArtB or PltB (24) are shown on dark blue background. Amino acid residues conserved in all three sequences (59) are indicated by an asterisk below the sequence alignment. (B) Predicted 3D structure of PltB and ArtB based on translated amino acid sequences of pltB and artB extracted from S. Javiana strain CFSAN0001992, generated using SWISS-MODEL online software (60).