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. 2018 Mar 27;9(2):e02229-17. doi: 10.1128/mBio.02229-17

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Copyright © 2018 Herrero-de-Dios et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 5 — Hog1 C156S, C161S, and C271S mutations differentially impact the sensitivity to phagocytic killing and virulence of C. albicans. (A) The sensitivity of C. albicans to phagocytic killing was assayed by counting fungal CFU after 2 h of exposure to human PMNs (1:10 ratio of yeast cells to phagocytes). PBS, phosphate-buffered saline control; HOG1/HOG1, RM1000+CIp20; HOG1/hog1, Ca2226; hog1/hog1, JC50; C156S, Ca2222; C161S, Ca2224; C156/161S, Ca2225; C271S, Ca2216 (Table S1). Means and standard deviations from three independent replicate experiments are shown. ns, not significant; ***, P < 0.001; ****, P < 0.0001. (B) Levels of virulence of the same C. albicans strains were compared in the Galleria model of systemic infection (20 larvae per fungal strain). The data were analyzed statistically using the log-rank (Mantel-Cox) test. ns, not significant; *, P < 0.05; **, P < 0.01.