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. 2018 Mar 28;25:28. doi: 10.1186/s12929-018-0432-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Antiproliferative effect of MPT0B098 in OEC-M1 cells under normoxic and hypoxic conditions. a The chemical structure of MPT0B098. b The in vitro antiproliferative activity of MPT0B098 in OEC-M1 cells under normoxic and hypoxic conditions. OEC-M1 cells were treated with MPT0B098, colchicine, or paclitaxel under normoxic and hypoxic conditions for 72 h. The IC₅₀ values of these compounds resulting from 50% inhibition of cell growth were calculated using the methylene blue dye assay. Each value represents the mean ± SD of three independent experiments. c Hypoxia-induced drug resistance is the IC₅₀ value of the test compounds in hypoxia divided by the equivalent in normoxia (* p < 0.05)