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. 2018 Mar 28;25:28. doi: 10.1186/s12929-018-0432-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of MPT0B098 and other microtubule inhibitors on the expression of EMT-related proteins in OEC-M1 cells under hypoxic conditions. a Parallel comparison of the effects of MPT0B098, colchicine, and paclitaxel on the expression of vimentin, N-cadherin, and E-cadherin in OEC-M1 cells.OEC-M1 cells were treated with various concentrations,indicated as fold of IC₅₀ values,of MPT0B098, colchicine, or paclitaxel for 36 h under hypoxic conditions. At the end of the drug treatment, cell lysates were prepared and analyzed by SDS-PAGE and Western blot. GAPDH was used as an internal control. b Each bar depicts the mean of the relative intensity of vimentin, N-cadherin, and E-cadherin from three independent experiments (* p < 0.05, compared to hypoxia control).