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. 2018 Mar 28;25:28. doi: 10.1186/s12929-018-0432-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MPT0B098 suppresses hypoxia-induced EMT by inhibiting the expression of EMT-activating transcription factors, Twist and SNAI2/Slug. a The effects of MPT0B098 on the expression of Twist and SNAI2/Slug in OEC-M1 cells.OEC-M1 cells were treated with various concentrations, indicated as fold of IC₅₀ values, of MPT0B098 for 18 and 36 h under hypoxic conditions. At the end of the drug treatment, cell lysates were prepared and analyzed by SDS-PAGE and Western blot. GAPDH was used as an internal control. Each values depicts the mean of the relative intensities of Twist and SNAI2/Slug from three independent experiments. b Each value depicts the mean of the relative intensities of Twist and SNAI2/Slug from three independent experiments (* p < 0.05, compared to hypoxia control)