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. 2018 Mar 29;10:26. doi: 10.1186/s13073-018-0530-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Molecular pathways affected by neuronal expression of Aβ42 overlap with those affected by glial TREM2/TYROBP. a Number of DEGs. The numbers of upregulated genes are indicated in red and the numbers of downregulated genes are in blue. b Heatmap showing the top functional pathways enriched in the DEGs identified in (a). The heatmap color intensity denotes the statistical significance of the enrichment (FDR at minus log 10 scale). c Overlaps among DEGs identified in (a). The number in each cell indicates the number of common DEGs between row and column variables, with color intensity indicating the FDR adjusted p value at minus log 10 scale. Genotypes of flies are described in Additional file 2: Table S1