Comparison 3.

Mefloquine versus cotrimoxazole

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal peripheral parasitaemia at delivery (PCR)	1	98	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.03, 1.72]
2 Placental malaria (PCR)	1	94	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.13, 4.15]
3 Placental malaria (blood smear)	1	108	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.01, 8.30]
4 Mean haemoglobin at delivery	1	100	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐0.67, 0.47]
5 Maternal anaemia at delivery (< 9.5 g/dL)	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.26, 3.16]
6 Mean birth weight	1	120	Mean Difference (IV, Fixed, 95% CI)	‐102.0 [‐255.52, 51.52]
7 Low birth weight	1	120	Risk Ratio (M‐H, Fixed, 95% CI)	1.52 [0.56, 4.13]
8 Prematurity	1	125	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.33, 3.56]
9 SAEs during pregnancy	1	140	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.28, 4.07]
10 Stillbirths	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	4.30 [0.49, 37.49]
11 Spontaneous abortions	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.07, 16.84]
12 Congenital malformations	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.16, 7.41]
13 Maternal mortality	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
14 Neonatal mortality	1	129	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.07, 16.39]
15 Infant deaths after 7 days	1	129	Risk Ratio (M‐H, Fixed, 95% CI)	2.10 [0.19, 22.54]
16 AEs: vomiting	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	13.43 [3.31, 54.54]
17 AEs: fatigue/weakness	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	6.99 [1.64, 29.81]
18 AEs: dizziness	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	52.60 [3.26, 848.24]
19 AEs: headache	1	139	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.01, 4.39]