Table 2.

Spontaneous tumorigenesis in wild-type and MTH1-deficient mice

Organ	Type of tumor	Male		Female
		−/−	+/+	−/−	+/+
Lung	Carcinoma	2	1	3	1
	Adenoma	5	2	5	0
	No. of mice with tumors (%)	7 (17)	3 (7)	8 (16)	1 (2)
Liver	Hepatocellular carcinoma	10	2	0	0
	Adenoma	6	4	2	0
	No. of mice with tumors (%)	16 (38)	6 (13)	2 (4)	0 (0)
Stomach	Carcinoma	2	1	0	0
	Adenoma	4	1	2	0
	No. of mice with tumors (%)	6 (14)	2 (4)	2 (4)	0 (0)
	Total no. of mice examined	42	46	51	44