Table 1.
Clinical and laboratory data of healthy controls and patients with early and advanced NASH
| Healthy controls (n=14) | Early NASH (n=24) | Advanced NASH (n=9) | |
|---|---|---|---|
| Men/Women | 9/5 | 18/6 | 6/3 |
| Age (years) | 51.9±13.2 | 46.1±9.6 | 64.1±11.5 |
| BMI (kg/m2) | 23.2±2.95 | 28.5±4.7† | 25.7±2.5‡ |
| Diabetes | 0 | 3 (12.5%) | 6 (66.7%) |
| Metabolic syndrome | 0 | 12 (50.0%) | 6 (66.7%) |
| AST (IU/L) | 21.0±4.3 | 54.5±29.5† | 60.9±24.9† |
| ALT (IU/L) | 18.7±5.0 | 89.7±57.2† | 71.0±25.4†‡ |
| γ-GTP (IU/L) | 23.7±10.2 | 62.0±52.5† | 163.5±50.6†§ |
| TC (mg/dL) | 208.1±25.6 | 211.0±43.6 | 173.3±26.2†§ |
| LDL (mg/dL) | 135.3±22.3 | 132.0±32.2 | 88.8±13.3*‡ |
| HDL (mg/dL) | 55.2±16.2 | 46.4±8.9 | 53.5±25.4 |
| TG (mg/dL) | 92.9±43.0 | 208.6±155.2† | 135.7±79.3‡ |
| BS (mg/dL) | 94.3±8.3 | 113.4±44.1† | 143.8±42.5*‡ |
| HbA1c (%) | 5.6±0.4 | 6.2±1.2† | 7.1±1.1*‡ |
| Plt (103/μL) | 242.6±65.5 | 213.9±63.0 | 141.0±37.7*‡ |
| Histological characteristics | |||
| Steatosis grade (1/2/3) | 4/15/5 | 4/5/0 | |
| Ballooning grade (1/2) | 9/15 | 5/4 | |
| Inflammation grade (1/2/3) | 11-11-2 | 2/5/2 | |
| Fibrosis stage (1/2/3/4) | 14/10/0/0 | 0/0/3/6 |
Values indicate mean ± standard deviation (SD).
NASH, nonalcoholic steatohepatitis; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyl transpeptidase; TC, total cholesterol; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; TG, triglyceride; BS, blood sugar; HbA1c, hemoglobin A1c; Plt, platelet.
These values in NASH patients vs. those in healthy controls, *P <0.05, †P <0.01; Advanced stage vs. early stage of NASH, ‡P <0.05, §P < 0.01.