Table 2.
Serum levels of MMPs, TIMPs and cytokines in healthy controls and patients with early NASH and advanced NASH
| Healthy controls (n=14) | Early NASH (n=24) | Advanced NASH (n=9) | |
|---|---|---|---|
| MMP-1 (ng/mL) | 0.96±0.55 | 1.71±1.63 | 1.38±0.35 |
| MMP-2 (ng/mL) | 30.7±10.8 | 33.5±12.4 | 52.0±19.2* |
| MMP-9 (ng/mL) | 24.0±14.8 | 33.7±25.7 | 16.9±6.7 |
| TIMP-1 (ng/mL) | 119.5±24.1 | 125.6±23.7 | 150.7±38.8* |
| TIMP-2 (ng/mL) | 57.1±27.0 | 54.2±10.0 | 66.3±20.4 |
| SDF-1α (pg/mL) | 133.4±45.6 | 230.2±182.4† | 371.3±227.5† |
| SCF-1 (pg/mL) | 89.3±24.7 | 100.2±46.1 | 105.7±20.8 |
| SCGF-β (ng/mL) | 12.0±7.0 | 18.0±13.6 | 19.6±11.9† |
| MCP-1 (pg/mL) | 35.2±10.4 | 55.1±22.2* | 54.2±23.6† |
| G-CSF (pg/mL) | 0.25±0.81 | 2.24±2.19* | 1.24±2.07 |
| Leptin (pg/mL) | 2,348.5±2,831.2 | 6,134.6±4,347.0† | 4,020.0±2,124.6* |
| Ghrelin (pg/mL) | 325.4±161.2 | 405.0±453.2 | 219.1±227.2 |
Values indicate mean ± standard deviation (SD).
MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; NASH, nonalcoholic steatohepatitis; SDF, stromal cell-derived factor; SCF, stem cell factor; SCGF-β, stem cell growth factor-β; MCP, monocyte chemotactic protein; G-CSF, granulocyte-colony stimulating factor.
Serum levels of MMPs/TIMPs and cytokines in NASH patients vs. those in healthy controls, *P <0.05, †P <0.01.