Table 4.
Serum levels of cytokines in NASH patients by grade of histological characteristics compared with those in healthy controls
| SDF-1α (pg/mL) | SCF-1 (pg/mL) | SCGF-β (ng/mL) | MCP-1 (pg/mL) | G-CSF (pg/mL) | Leptin (ng/mL) | Ghrelin (pg/mL) | ||
|---|---|---|---|---|---|---|---|---|
| Healthy controls | 97.8±77.9 | 89.3±26.8 | 12±10 | 35.2±11.6 | 0.24±0.81 | 2.35±1.91 | 325.4±157.2 | |
| Steatosis | 1 | 302.0±215.0† | 117.9±63 | 16.2±8.2 | 52.2±25.3 | 2.94±6.21 | 5.42±5.84 | 478.5±698.7 |
| 2 | 322.5±206.8† | 98.3±26 | 20.9±15.9 | 53.2±20.7* | 2.00±2.37 | 4.97±2.53 | 310.5±191.6 | |
| 3 | 115.2±77.5 | 88.2±7.3 | 14.8±3.6 | 64.9±25.7* | 3.25±1.29 | 6.70±4.01 | 188.8±126.5 | |
| Inflammation | 1 | 233.8±109.5* | 113.2±55.2 | 14.6±7.0 | 51.5±24.0 | 1.66±2.29 | 4.83±3.34 | 274.4±142.3 |
| 2 | 319.3±263.7† | 89.8±18.7 | 21.6±16.0 | 59.5±22.2† | 3.44±4.71* | 5.82±4.46 | 430.9±544.5 | |
| 3 | 327.5±192.9 | 115.3±18.1 | 20.1±13.4 | 46.9±18.6 | 1.24±1.17 | 5.42±3.24 | 179.2±120.9 | |
| Ballooning | 1 | 254.5±151.8* | 108.8±48.7 | 15.6±7.6 | 51.2±26.9 | 2.21±4.57 | 5.07±3.04 | 304.2±211.2 |
| 2 | 237.4±242.6† | 93.7±17.8 | 22.4±16.9* | 59.4±14.2† | 2.78±2.08 | 5.76±4.71* | 381.2±554.6 | |
| Fibrosis | 1 | 182.7±100.7 | 104.1±54.5 | 21.6±15.2 | 63.6±20.6† | 2.72±2.53* | 6.98±4.84† | 474.4±535.4 |
| 2 | 323.4±216.0† | 91.6±19.9 | 10.3±1.4 | 36.4±12.5 | 1.53±1.81 | 4.28±2.44* | 252.5±105.6 | |
| 3 | 344.1±241.9* | 103.8±20.7 | 21.6±12.9 | 56.6±31.5 | 1.18±1.09 | 5.29±2.33* | 160.4±278.4 | |
| 4 | 430.7±274.0† | 107.2±23.2 | 18.0±12.3 | 52.3±18.8 | 0.79±1.76 | 3.01±1.43 | 266.1±197.1 |
Values indicate mean ± standard deviation (SD).
NASH, nonalcoholic steatohepatitis; SDF, stromal cell-derived factor; SCF, stem cell factor; SCGF-β, stem cell growth factor-β; MCP, monocyte chemotactic protein; G-CSF, granulocyte-colony stimulating factor.
Serum levels of cytokines in NASH patients vs. those in healthy controls, *P <0.05, †P <0.01.