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. 2018 Apr;24(4):718–726. doi: 10.3201/eid2404.170141

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Distribution of IC₅₀ of Plasmodium falciparum values by dihydroartemisinin in conventional ex vivo drug susceptibility assay. IC₅₀ values to dihydroartemisinin in conventional ex vivo drug susceptibility assay are plotted. Geometric mean IC₅₀ values in isolates with survival rates of 0, >0 to <10%, and >10% (high RSA survival) were 3.0 nmol/L (n = 74), 1.9 nmol/L (n = 14), and 3.3 nmol/L (n = 3), respectively. In the conventional ex vivo drug susceptibility assay, replication of parasites was monitored after continuous exposure to dihydroartemisinin for 72 h. Dashed line indicates geometric mean IC₅₀ value of all isolates (2.25 nmol/L). IC₅₀, concentration needed to inhibit 50% growth; RSA, ring-stage survival assay.