Table 2. Hazard Ratios for the Combined Outcome and All-Cause Mortality.
| Outcome | All Patients | Biventricular Circulation | Fontan Circulation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No (%), ACR ≥30 vs <30 mg/g | HR (95% CI) | P Value | No (%), ACR ≥30 vs <30 mg/g | HR (95% CI) | P Value | No (%), ACR ≥30 vs <30 mg/g | HR (95% CI) | P Value | |
| Combined outcomea | |||||||||
| ACR ≥30 mg/g, univariate | 30/106 (28.3) vs 38/506 (7.5) |
3.0 (1.9-4.9) |
<.001 | 25/82 (30.5) vs 21/444 (4.7) |
4.5 (2.5-8.0) |
<.001 | 5/24 (20.8) vs 17/62 (27.4) |
1.0 (0.4-2.8) |
.95 |
| ACR ≥30 mg/g, adjusted model 1b | NA | 2.4 (1.4-4.1) |
.002 | NA | 2.6 (1.3-5.4) |
.01 | NA | 0.9 (0.3-2.9) |
.89 |
| ACR ≥30 mg/g, adjusted model 2c | NA | 2.2 (1.3-4.0) |
.01 | NA | 2.6 (1.2-5.6) |
.01 | NA | 0.9 (0.3-3.0) |
.85 |
| Mortalityd | |||||||||
| ACR ≥30 mg/g | 11/106 (10.4) vs 6/506 (1.2) |
6.4 (2.4-17.3) |
<.001 | 10/82 (12.2) vs 1/444 (0.2) |
37.9 (4.8-297) |
<.001 | 1/24 (4.2) vs 5/62 (8.1) |
0.6 (0.1-5.4) |
.67 |
Abbreviations: ACR, albumin-to-creatinine ratio; HR, hazard ratio; NA, not applicable.
a
The combined outcome was mortality or nonelective cardiovascular hospitalization; the combined outcome and mortality alone were each associated with albuminuria in the overall cohort.
b
Model 1 was based on automated forward selection and was adjusted for New York Heart Association functional class and cyanosis.
c
Model 2 was adjusted for age, diabetes mellitus, New York Heart Association functional class, cyanosis, congenital heart disease severity, and estimated glomerular filtration rate.
d
Given the low absolute number of deaths (n = 17), multivariable adjustment was not performed for mortality alone.