Table 2. Hazard Ratio of Incident Coronary Heart Disease by Quartiles of Fibroblast Growth Factor 23 (FGF23) Concentration.
| Model | Hazard Ratio (95% CI) | ||||
|---|---|---|---|---|---|
| FGF23 Concentration | Per Doubling of FGF23 Concentration | ||||
| Quartile 1 (<53 RU/mL) | Quartile 2 (53-70 RU/mL) | Quartile 3 (>70-100 RU/mL) | Quartile 4 (>100 RU/mL) | ||
| Events, No. | 122 | 183 | 208 | 316 | 829 |
| Model 1a | 1 [Reference] | 1.67 (1.19-2.34) | 1.90 (1.36-2.67) | 3.79 (2.67-5.39) | 1.59 (1.38-1.85) |
| Model 2b | 1 [Reference] | 1.83 (1.25-2.69) | 1.64 (1.10-2.44) | 2.85 (1.89-4.30) | 1.46 (1.25-1.71) |
| Model 3c | 1 [Reference] | 1.71 (1.14-2.58) | 1.43 (0.92-2.23) | 2.15 (1.35-3.42) | 1.48 (1.20-1.81) |
Abbreviation: RU, relative unit.
Adjusted for race, age, and sex. P value for linear trend for model 1 < .001.
Adjusted for variables in model 1 plus body mass index, systolic blood pressure level, diastolic blood pressure level, diabetes, physical activity, income, education, neighborhood socioeconomic characteristics, cigarette smoking, left ventricular hypertrophy, and use of aspirin, statins, and renin-angiotensin-aldosterone system inhibitors. P value for linear trend for model 2 < .001.
Adjusted for variables in model 2 plus estimated glomerular filtration rate, natural log–transformed albumin to creatinine ratio, natural log–transformed C-reactive protein level, intact parathyroid hormone concentration, triglyceride level, high-density lipoprotein cholesterol level, and total cholesterol level. P value for linear trend for model 3 = .005.