Table 3. Hazard Ratios of Incident Coronary Heart Disease by Quartiles of Fibroblast Growth Factor 23 (FGF23) Concentration Stratified by Sex.
| Model | Hazard Ratio (95% CI) | ||||
|---|---|---|---|---|---|
| FGF23 Concentration | Per Doubling of FGF23 Concentration | ||||
| Quartile 1 (<53 RU/mL) | Quartile 2 (53-70 RU/mL) | Quartile 3 (>70-100 RU/mL) | Quartile 4 (>100 RU/mL) | ||
| Men | |||||
| Events, No. | 80 | 133 | 129 | 162 | 504 |
| Model 1a | 1 [Reference] | 2.07 (1.37-3.14) | 2.12 (1.39-3.24) | 5.08 (3.19-8.09) | 2.48 (1.96-3.16) |
| Model 2b | 1 [Reference] | 2.25 (1.39-3.63) | 1.71 (1.04-2.82) | 3.49 (2.00-6.11) | 2.36 (1.79-3.11) |
| Model 3c | 1 [Reference] | 2.18 (1.32-3.59) | 1.54 (0.89-2.66) | 2.40 (1.30-4.42) | 1.79 (1.27-2.53) |
| Women | |||||
| Events, No. | 42 | 50 | 79 | 154 | 325 |
| Model 1a | 1 [Reference] | 0.96 (0.56-1.63) | 1.36 (0.82-2.25) | 2.16 (1.34-3.49) | 1.38 (1.18-1.63) |
| Model 2b | 1 [Reference] | 1.09 (0.58-2.09) | 1.36 (0.72-2.59) | 1.94 (1.08-3.49) | 1.25 (1.04-1.50) |
| Model 3c | 1 [Reference] | 0.94 (0.48-1.84) | 1.08 (0.53-2.23) | 1.51 (0.79-2.86) | 1.44 (1.08-1.91) |
| Model 4d | 1 [Reference] | 1.27 (0.54-2.99) | 1.60 (0.67-3.81) | 2.34 (1.04-5.27) | 1.48 (1.11-1.97) |
Abbreviation: RU, relative unit.
Adjusted for race and age. P value for interaction by sex = .06.
Adjusted for variables in model 1 plus body mass index, systolic blood pressure level, diastolic blood pressure level, diabetes, physical activity, income, education, neighborhood socioeconomic characteristics, cigarette smoking, left ventricular hypertrophy, and use of aspirin, statins, and renin-angiotensin-aldosterone system inhibitors. P value for interaction by sex = .08.
Adjusted for variables in model 2 plus estimated glomerular filtration rate, natural log–transformed albumin to creatinine ratio, natural log–transformed C-reactive protein level, intact parathyroid hormone concentration, triglyceride level, high-density lipoprotein cholesterol level, and total cholesterol level. P value for interaction by sex = .07.
Adjusted for variables in model 3 plus hormone therapy in women with available data.