Table 4. Hazard Ratio of Incident Coronary Heart Disease as a Function of Baseline, Sex-Specific Quartiles of Fibroblast Growth Factor 23 (FGF23) Concentration.
| Model | FGF23 Concentration, Hazard Ratio (95% CI) | |||
|---|---|---|---|---|
| Quartile 1 (Men, <48 RU/mL; Women, <56 RU/mL) | Quartile 2 (Men, 48-61 RU/mL; Women, 56-73 RU/mL) | Quartile 3 (Men, >61-76 RU/mL; Women, >73-109 RU/mL) | Quartile 4 (Men, >76 RU/mL; Women, >109 RU/mL) | |
| Men | ||||
| Events, No. | 57 | 96 | 95 | 256 |
| Model 1a | 1 [Reference] | 1.73 (1.08-2.77) | 1.56 (0.96-2.53) | 4.37 (2.78-6.87) |
| Model 2b | 1 [Reference] | 1.86 (1.07-3.23) | 1.53 (0.88-2.68) | 3.77 (2.19-6.47) |
| Model 3c | 1 [Reference] | 2.03 (1.11-3.74) | 1.31 (0.72-2.40) | 2.65 (1.43-4.90) |
| Women | ||||
| Events, No. | 54 | 45 | 95 | 131 |
| Model 1a | 1 [Reference] | 0.82 (0.49-1.39) | 1.47 (0.91-2.38) | 2.17 (1.35-3.48) |
| Model 2b | 1 [Reference] | 1.28 (0.59-2.78) | 1.71 (0.86-3.39) | 1.99 (1.02-3.86) |
| Model 3c | 1 [Reference] | 0.91 (0.36-2.25) | 1.69 (0.79-3.57) | 2.26 (1.02-5.03) |
| Model 4d | 1 [Reference] | 0.99 (0.39-2.51) | 1.81 (0.84-3.92) | 2.39 (1.05-5.44) |
Abbreviation: RU, relative unit.
Adjusted for race and age.
Adjusted for variables in model 1 plus body mass index, systolic blood pressure level, diastolic blood pressure level, diabetes, income, education, neighborhood socioeconomic characteristics, physical activity, cigarette smoking, left ventricular hypertrophy, and use of aspirin, statins, and renin-angiotensin-aldosterone system inhibitors.
Adjusted for variables in model 2 plus estimated glomerular filtration rate, natural log–transformed albumin to creatinine ratio, natural log–transformed C-reactive protein level, intact parathyroid hormone concentration, triglyceride level, high-density lipoprotein cholesterol level, and total cholesterol level.
Adjusted for variables in model 3 plus hormone therapy in women with available data.