Figure 2. Change From Baseline to Follow-up in Left Hippocampal Volumetric Integrity (LHVI) by Time Since Onset of Psychosis in Participants With First-Episode Psychosis (FEP).

The solid lines indicate individual participants with FEP; HC indicates the median LHVI value for healthy controls. Hippocampal volumetric integrity, defined as the parenchymal fraction of a standardized volume of interest that is expected to encompass the hippocampus in a healthy brain, was calculated using a fully automated procedure in which the volume of interest is estimated for each hemisphere using automatically detected landmarks and the tissue fraction is estimated by histogram analysis.