Table 3. Significant Results From LASSO Multivariate Association Model of Baseline and Change in LHVI.
| Baseline LHVI Factorsa | Parameter Estimate | SE | 95% CI | P Value |
|---|---|---|---|---|
| IL-8 | −0.000273 | 0.0001146 | −0.00049 to 4.816E−5 | .02 |
| IFN-γ | 0.0003771 | 0.0001557 | 7.1923E−5 to 0.0006822 | .02 |
| NOS1 (CC) | 0.0295961 | 0.0093529 | 0.0112649 to 0.0479274 | .002 |
| BDNF (GG) | 0.0235826 | 0.0091729 | 0.005604 to 0.0415612 | .01 |
| IFN-γ × DUP | 1.3282E-5 | 6.3559E-6 | 8.2421E−7 to 2.574E−5 | .04 |
| IL-8 × DUP | 7.2689E-5 | 0.0000127 | 4.7779E−5 to 0.0000976 | .001 |
| NOS1 (CC) × DUP | 0.0021139 | 0.0005374 | 0.0010606 to 0.0031673 | .001 |
| BDNF (AA) × DUP | 0.002997 | 0.0009478 | −0.004855 to 0.001139 | .002 |
| ZNF804A (GG) × DUP | 0.0012497 | 0.0002708 | 0.000719 to 0.0017803 | .001 |
| COMT (GA) × DUP | −0.00142 | 0.000502 | −0.002404 to 0.000437 | .005 |
| Change in LHVI factors | ||||
| S100B | −0.016025 | 0.0016714 | −0.019301 to −0.012749 | .001 |
| S100B × DUP | −0.000801 | 0.000159 | −0.001112 to −0.000489 | .001 |
| Thioredoxin × DUP | −0.000159 | 2.7019E-5 | −0.000212 to −0.000106 | .001 |
| NOS1 (CC) × DUP | −0.241284 | 0.0811758 | −0.400386 to −0.082182 | .003 |
Abbreviations: BDNF, brain-derived neurotrophic factor; COMT, catechol-O-methyltransferase; DUP, duration of untreated psychosis; IFN-γ, interferon γ; IL-8, interleukin 8; LASSO, least absolute shrinkage and selection operator; LHVI, left hippocampal volumetric integrity; NOS1, nitric oxide synthase 1; S100B, S100 calcium binding protein B; ZNF804A, zinc finger protein 804A.
a
Parenthetic capital letters CC, GG, AA, and GA refer to genotypes.