Table 3.
Association between cognitive activities in each life period and Aβ and AD-signature region neurodegeneration (AD-ND) positivity.
| Adjusted OR | 95% CI | P | PB | |
|---|---|---|---|---|
| Aβ positivity | ||||
| Early life | 0.840 | 0.500–1.410 | 0.51 | >0.99 |
| Midlife | 0.939 | 0.594–1.482 | 0.79 | >0.99 |
| Late life | 0.786 | 0.484–1.277 | 0.33 | >0.99 |
| AD-ND positivity | ||||
| Early life | 0.648 | 0.427–0.983 | 0.04 | 0.13 |
| Midlife | 0.790 | 0.550–1.134 | 0.20 | 0.60 |
| Late life | 0.712 | 0.483–1.050 | 0.09 | 0.26 |
OR, odds ratio; CI, confidence interval; Aβ, amyloid-beta; AD-ND, Alzheimer’s disease signature region neurodegeneration. The results of the independent multiple logistic regression model with age, gender, education, and apolipoprotein E ε4 as covariates are presented. PB: P-value corrected by Bonferroni’s method.