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NIA-AA Criteria for preclinical AD research (adapted from (2))
| Stages | A β (PET or CSF) | Neuronal injury markers (FDG, tau, MRI) | Subtle cognitive change |
|---|---|---|---|
| Stage 1 (Asymptomatic cerebral amyloidosis) | Positive | Negative | Negative |
| Stage 2 (Amyloid positivity + synaptic dysfunction and/or neurodegeneration) | Positive | Positive | Negative |
| Stage 3 (Amyloid positivity + neurodegeneration + subtle cognitive decline) | Positive | Positive | Positive |
