Partial regression residual plot of the associations between tumor necrosis factor receptors (TNFRs), percent of normal endothelial cell fenestration (ECF), and mesangial fractional volume (VvMes). The residuals were computed from regressing each of the following variables: age, sex, diabetes duration, hemoglobin A1c, body mass index, and mean arterial pressure. Exclusion of the single outlier did not change the significance of associations between 2 morphometric variables. Reprinted with permission from Pavkov ME, Weil EJ, Fufaa GD, et al. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016;89:226–234. Copyright © International Society of Nephrology. Reprinted with permission from Looker HC and Nelson RG. Reading the tree leaves – how to enrich clinical trials of diabetic kidney disease Kidney Int. 2017;92:23–2595.