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. 2018 Mar 29;6(6):e13654. doi: 10.14814/phy2.13654

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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UMOD expression amplifies UUO‐associated interstitial inflammation. Interstitial inflammation is a hallmark feature of kidney fibrosis. Interstitial macrophage density, quantified by kidney F4/80 protein western blotting (n = 5 for sham groups; n = 7 for UUO groups), was significantly lower in the UMOD−/− groups by 41–58% at all time‐points (A, B). Representative day 21 immunofluorescence photomicrographs illustrate a smaller interstitial area expressing the F4/80 macrophage protein (green) in the UMOD−/− kidney (C). Kidney MCP‐1 mRNA levels were significantly lower in the UMOD−/− mice on UUO days 7, 14, and 21 (n = 3 for sham groups; n = 7 for UUO groups) (D). Bar graphs represent means +1SEM; * indicates P value < 0.05. Photomicrograph magnification: ×40. Scale bar: 25 μm.