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. 2018 Mar 29;6(6):e13654. doi: 10.14814/phy2.13654

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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UMOD expression does not alter kidney fibrosis severity in UUO nephropathy. Total kidney collagen levels (μg/mg wet kidney weight) calculated using the hydroxyproline assay and presented as fold increase relative to sham values (A) and picrosirius red+ interstitial areas (B) were similar between the UMOD+/+ and UMOD−/− groups at all time‐points after UUO (n = 10 per group and n = 3–4 per group for the respective methods). Representative polarized light microscopic photomicrographs from day 21 kidney sections illustrate a similar extent of picrosirius red+ interstitial collagen deposits (yellow) (C). Kidney mRNA levels measured by real‐time PCR (n = 3 for sham groups; n = 5 for UUO groups) were similar for procollagen 1α1 (D) and procollagen 3α1 (E). Bar graphs represent means +1SEM. Photomicrograph magnification: ×40. Scale bar: 25 μm.