Table 4.
Summary of all available Genomes for Life (GCAT) data
| Data type | Number of participants | Details | Date of acquisition | Date available for research |
| Baseline assessment | Whole cohort | Questionnaire, physical measures, samples | 2014–2017 | 2018 |
| Repeat of baseline assessment | Whole cohort | Questionnaire follow-up every 2 years | 2018 | 2019 |
| Genotyping (baseline samples) | 5459 (GCATcore) | Dense genotyping array with 666 695 markers after quality control (see figure 2) | 2016 | 2018 |
| Genotyping extended (baseline samples) | 5459 (GCATcore) | Dense genotyping map with 15 078 461 variants (see figure 2) by in silico imputation (IMPUTE) | 2017–2018 | 2018 |
| Food frequency web questionnaire (follow-up) | Whole cohort | Participants are invited by email to provide additional information about diet; estimates of nutrient intake | 2017–2018 | 2018 |
| Biochemical assay (baseline samples) | 6000 | Glycated haemoglobin (haemoglobin A1c) | 2016–2017 | 2018 |
| Metabolome (baseline samples) | 5000 (GCATcore) | Biomarkers with known disease association (lipids and vascular disease) | 2017–2018 | 2018 |
| Chronotype web questionnaire (follow-up) | Whole cohort | Participants are invited by email to provide additional information (ie, sleep behaviour, circadian rhythm, and work shift) | 2017–2018 | 2018 |
| Exposome (baseline) | Whole cohort | Map of environmental exposures acquired with geographical information system (GIS) technology | 2017–2018 | 2018 |
| Other web-based questionnaire data (follow-up) | Whole cohort | Participants are invited by email to provide additional information via web about working places. Information will be integrated with exposome assessment | 2017–2018 | 2018 |
| Exome | 200 (GCATcore) | Clinic custom exome of hereditary cancer in 126 hereditary cancer genes (400×) | 2017 | 2018 |
| Whole-genome sequencing | 808 | 30× whole genome sequencing from 1000 volunteers, 20% from GCATcore | 2017–2018 | 2018 |
| Epigenome | 150 | DNA methylation epigenomic profile using Infinum Methylation EPIC 850K beadarray assay | 2018 | 2019 |
| Health record linkage | ||||
| Primary care | Whole cohort | ICD/ATC/ OPCS procedures/laboratory | 2017–2018 | 2018 |
| Death registrations | Whole cohort | ICD-coded cause specific mortality | 2017–2018 | 2018 |
| Hospital inpatient | Whole cohort | ICD/ATC/OPCS procedures/laboratory | 2017–2018 | 2018 |
| Hospital outpatient | Whole cohort | ICD (few)/OPCS | 2018 | 2018 |
| Other | Whole cohort | National mental healthcare/national social healthcare | 2018 | 2018 |
ATC, Anatomical Therapeutic Chemical Classification System; EPIC, European Prospective Investigation into Cancer and Nutrition; ICD, International Statistical Classification of Diseases; OPCS, Classification of Interventions and Procedures.