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. Author manuscript; available in PMC: 2018 Mar 29.
Published in final edited form as: J Hepatol. 2017 May 26;67(4):716–726. doi: 10.1016/j.jhep.2017.05.021

Fig. 6. P2X7 receptor blockade and concurrent adenosine A2A receptor activation inhibit inflammatory cytokine production and NF-κB/STAT3 activation in the liver from septic WT or CD39−/− mice.

Fig. 6

The liver was harvested 24 h after surgery and (A) cytokine (IL-1β, IL-6, TNF-α, and IL-10) production were determined by ELISA. (B) MyD88, p-NF-κB and p-STAT3 protein levels in the liver from septic mice treated or not treated with BBG or BBG + ATL146e. Data are presented as mean ± SEM from three independent experiments (n = 6) analyzed by one-way ANOVA, Turkey tests. Statistically significant differences between Sham and CLP, and between CLP groups (CLP vehicle vs. CLP BBG, CLP vehicle vs. CLP BBG + ATL146e) are indicated by asterisks (*, p <0.05; **, p <0.01; ***, p <0.001) and by the number sign (#, p <0.05), respectively.