Table 1.
Performance of Xpert in adults and children.
| Detect | Specimen | Population | Reference method | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|---|
| TB | Sputum | Adults | Culture | 88% (84–92%) | 99% (98–99%) |
| TB | Sputum | Adults, smear+ | Culture | 98% (97–99%) | N/A |
| TB | Sputum | Adults; smear− | Culture | 68% (61–74%) | 99% (98–99%) |
| TB | Sputum | HIV+ adults | Culture | 79% (70–86%) | 98% (96–99%) |
| TB | Sputum | HIV–adults | Culture | 86% (76–92%) | 99% (98–100%) |
| TB | Sputum | Children | Culture | 66% (52–77%) | 98% (96–100%) |
| TB | Gastric aspirate | Children | Culture | 66% (51–81%) | 98% (96–100%) |
| TB | Lymph node tissue, aspirate | Adults and children | Culture | 85% (72–92%) | 93% (80–97%) |
| TB | Other tissue type | Adults and children | Culture | 81% (68–90%) | 98% (87–100%) |
| TB | Cerebral spinal fluid | Adults and children | Culture | 80% (62–90%) | 99% (96–100%) |
| RIF-R | Adults | Culture DST | 95% (90–97%) | 98% (97–99%) | |
| RIF-R | Children | Culture DST | 86% (53–98%) | 98% (94–100%) |